Which syndrome is associated with intermittent abdominal pain, diarrhea, and weight loss?

Intermittent abdominal pain, diarrhea, and weight loss are key symptoms often associated with irritable bowel syndrome (IBS). This functional gastrointestinal disorder is characterized by a combination of abdominal discomfort, changes in bowel habits, including diarrhea and constipation, and can be accompanied by other symptoms such as bloating. Weight loss can occur in IBS, particularly if the symptoms lead to dietary restrictions or inadequate caloric intake due to fear of triggering symptoms.

In contrast, celiac disease typically presents with additional symptoms such as malabsorption due to gluten intolerance, which can lead to specific nutrient deficiencies, rather than just intermittent abdominal pain and diarrhea. Gastroesophageal reflux disease primarily presents with heartburn and regurgitation rather than abdominal pain and diarrhea. Peptic ulcer disease usually manifests with epigastric pain that is cyclic and often related to meals, but it does not typically present with diarrhea or significant weight loss unless there are severe complications. Thus, the features of intermittent abdominal pain, diarrhea, and weight loss align most closely with IBS, making it the most appropriate answer for this question.