What is the recommended treatment for acute migraines?

Triptans are specifically designed to target migraine headaches by acting on serotonin receptors, particularly the 5-HT_1B and 5-HT_1D subtypes. These medications help alleviate migraine symptoms by causing vasoconstriction of cranial blood vessels and inhibiting the release of pro-inflammatory neuropeptides. Their efficacy in treating moderate to severe migraines makes them a first-line treatment option in acute attack management.

While ergots can also be effective for migraines, they are less commonly used due to their side effects and the availability of triptans, which tend to have a more favorable safety profile. Over-the-counter analgesics, such as acetaminophen or aspirin, may be effective for mild migraines but often don't provide sufficient relief for more intense episodes. NSAIDs like ibuprofen can also be used for pain relief, but triptans are generally preferred for their targeted action and effectiveness in treating moderate to severe migraines.