What is the recommended first-line treatment for osteoarthritis?

The recommended first-line treatment for osteoarthritis is acetaminophen. This choice is supported by clinical guidelines as a primary option for managing the pain associated with osteoarthritis. Acetaminophen is generally favored due to its effectiveness in relieving mild to moderate pain without the gastrointestinal side effects commonly associated with nonsteroidal anti-inflammatory drugs (NSAIDs).

Furthermore, acetaminophen has a favorable safety profile, making it a suitable option for many patients, including those who may have contraindications to NSAIDs, such as those with certain cardiovascular or gastrointestinal conditions. It's important to note that while NSAIDs can also be used in the treatment of osteoarthritis, they are often considered a secondary choice due to their potential for adverse effects, especially with long-term use.

Glucosamine supplements and corticosteroids are not typically recommended as initial treatments for osteoarthritis. While some patients may seek glucosamine for its purported benefits, evidence supporting its use is mixed, and it is not established as a first-line therapy. Corticosteroids may be considered for more severe inflammation or cases where other medications have failed but are not recommended as a routine first-line treatment due to their side effect profile and the potential for long-term complications.

In summary, acetaminophen is