What is the most common cause of folate deficiency?

Folate deficiency is most commonly linked to alcoholism because chronic alcohol consumption can significantly impair folate absorption and metabolism in the body. Alcohol interferes with the transport of folate across the intestinal mucosa and reduces the liver's ability to store and utilize folate, leading to diminished serum levels of this essential B vitamin. Additionally, individuals with alcoholism often have poor dietary habits, which further exacerbates the risk of folate deficiency.

While malnutrition is a potential cause of folate deficiency, particularly in populations with limited access to nutritious foods, alcohol's direct impact on folate metabolism makes it a more prevalent factor. Medications can cause folate deficiency as well, but this is less common when compared to the pervasive effects of alcoholism. Genetic disorders that affect folate metabolism do exist; however, they are relatively rare compared to the widespread issue of alcohol-related deficiencies. Therefore, alcoholism stands out as the leading cause of folate deficiency in the population.